Journal article
N. Bechmann, I. Berger, S. Bornstein, C. Steenblock
Molecular and Cellular Endocrinology, 2021
Molecular and Cellular Endocrinology, 2021
Semantic Scholar
DOI
PubMed
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APA
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Bechmann, N., Berger, I., Bornstein, S., & Steenblock, C. (2021). Adrenal medulla development and medullary-cortical interactions. Molecular and Cellular Endocrinology.
Chicago/Turabian
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Bechmann, N., I. Berger, S. Bornstein, and C. Steenblock. “Adrenal Medulla Development and Medullary-Cortical Interactions.” Molecular and Cellular Endocrinology (2021).
MLA
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Bechmann, N., et al. “Adrenal Medulla Development and Medullary-Cortical Interactions.” Molecular and Cellular Endocrinology, 2021.
BibTeX Click to copy
@article{n2021a,
title = {Adrenal medulla development and medullary-cortical interactions.},
year = {2021},
journal = {Molecular and Cellular Endocrinology},
author = {Bechmann, N. and Berger, I. and Bornstein, S. and Steenblock, C.}
}
Abstract
The mammalian adrenal gland is composed of two distinct tissue types in a bidirectional connection, the catecholamine-producing medulla derived from the neural crest and the mesoderm-derived cortex producing steroids. The medulla mainly consists of chromaffin cells derived from multipotent nerve-associated descendants of Schwann cell precursors. Already during adrenal organogenesis, close interactions between cortex and medulla are necessary for proper differentiation and morphogenesis of the gland. Moreover, communication between the cortex and the medulla ensures a regular function of the adult adrenal. In tumor development, interfaces between the two parts are also common. Here, we summarize the development of the mammalian adrenal medulla and the current understanding of the cortical-medullary interactions under development and in health and disease.