New Horizons: Novel Adrenal Regenerative Therapies

Journal article

S. Bornstein, Maria Malyukov, C. Heller, C. Ziegler, G. Ruiz-Babot, A. Schedl, B. Ludwig, C. Steenblock
Journal of Clinical Endocrinology and Metabolism, 2020

Semantic Scholar DOI PubMedCentral PubMed

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APA Click to copy
Bornstein, S., Malyukov, M., Heller, C., Ziegler, C., Ruiz-Babot, G., Schedl, A., … Steenblock, C. (2020). New Horizons: Novel Adrenal Regenerative Therapies. Journal of Clinical Endocrinology and Metabolism.

Chicago/Turabian Click to copy
Bornstein, S., Maria Malyukov, C. Heller, C. Ziegler, G. Ruiz-Babot, A. Schedl, B. Ludwig, and C. Steenblock. “New Horizons: Novel Adrenal Regenerative Therapies.” Journal of Clinical Endocrinology and Metabolism (2020).

MLA Click to copy
Bornstein, S., et al. “New Horizons: Novel Adrenal Regenerative Therapies.” Journal of Clinical Endocrinology and Metabolism, 2020.

BibTeX Click to copy

@article{s2020a,
  title = {New Horizons: Novel Adrenal Regenerative Therapies},
  year = {2020},
  journal = {Journal of Clinical Endocrinology and Metabolism},
  author = {Bornstein, S. and Malyukov, Maria and Heller, C. and Ziegler, C. and Ruiz-Babot, G. and Schedl, A. and Ludwig, B. and Steenblock, C.}
}

Abstract

Abstract Adrenal insufficiency requires lifelong corticoid replacement therapies. However, current therapies are not able to replace the physiological circadian pattern of the adrenal cortex and are associated with many metabolic, vascular, neuroendocrine, and mental perturbations. Therefore, regenerative and more curative strategies would be desirable. In the current perspective, we describe emerging new regenerative therapies for the treatment of adrenal insufficiency. In particular, we discuss gene therapy and cell replacement strategies. Furthermore, we discuss how adrenal cells might be used as a source for regenerative therapies of nonadrenal neurodegenerative diseases such as Parkinson disease.